Department of Bioinformatics – BiGCaT

Paper: Precision medicine in circadian rhythm sleep–wake disorders: current state and future perspectives

January 24th, 2017 by admin


In circadian rhythm sleep–wake disorders precision medicine is less developed than in other medical disciplines mainly because homeostatic sleep and circadian timing have a very complex phenotype with multiple genetic regulation mechanisms. However,
biomarkers, phenotyping and psychosocial characteristics are increasingly used.
Devices for polysomnography, actigraphy and sleep-tracking applications in mobile phones and other consumer devices with eHealth technologies are increasingly used.
Also sleep-related questionnaires and the assessment of co-morbidities influencing sleep in circadian rhythm sleep–wake disorders are major contributors to precision sleep medicine. To further strengthen the (pharmaco-)genetic and biomarker pillar, technology needs to be evolved further. Routinely measuring treatment results using patient-reported outcome measures and clinical neurophysiological instruments will boost precision sleep medicine.

Full paper:  Precision medicine in circadian rhythm sleep–wake disorders: current state and future perspectives

Melatonin metabolism pathway

Melatonin metabolism and effects pathway

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